Murray recovered from a break down to win the first set 6-4 with five straight games. He was up 2-0 in the second set when Nishikori retired from the match.
Murray will play Bulgarian player Grigor Dimitrov, who beat Marcos Baghdatis 6-3 5-7 7-6 in the other semi-final in Brisbane, in Sunday's final.
"I have no idea whether he'll be nervous or he'll enjoy the occasion - we'll find out tomorrow," said Olympic and US Open champion Murray, who beat Dimitrov in their only previous meeting, in the Thailand Open in 2011.
"Grigor plays with a lot of variety and he can play a lot of shots. He's one of the few guys coming through with a single-handed backhand, so he uses a lot more slice."
Nishikori injured his left knee on Friday during his quarter-final match against Alexandr Dolgopolov, and the problem increased during the night.
The Japanese player is hopeful that he will be able to play at the Australian Open, which starts on 14th January in Melbourne.
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